@agewellwithdrstep: Did you know that a class of common medications, including some allergy pills, bladder medications, and certain antidepressants, can quietly accumulate in your system over years and increase your risk of dementia, falls, and loss of independence? This is called anticholinergic burden, and the data is sobering. Just one month of daily use is associated with a 6% increased dementia risk. Three or more years of daily use is associated with a 49% increased risk, and that risk showed up even when researchers looked at medication use from 5 to 20 years before diagnosis. Every prescriber needs to ask: am I adding to this patient's lifetime anticholinergic burden? And every patient deserves to know the answer. Sources: • Coupland et al., JAMA Internal Medicine, 2019 • Dmochowski et al., Neurourology and Urodynamics, 2021 • Raad et al., British Journal of Clinical Pharmacology, 2026 #medicalresidency #doctors #aging #pharmacists #MedEd

AgeWellWithDrSteph
AgeWellWithDrSteph
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Saturday 29 August 2026 14:29:38 GMT
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phil68138
Phil68138 :
Lucky I take none of those
2026-09-04 01:52:20
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cauli346
cauli :
i took Benadryl daily for 20 years ......
2026-08-29 14:51:29
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odinandfrig
odinandfrig :
Do you have a way to check your meds? I have COMT and I'm the 1%er. "the med doesn't bother most people " but it bothers me.
2026-08-29 14:43:41
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learningtosee
learningtosee :
Is that what’s wrong with me? 😭
2026-08-29 19:15:37
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93et_
93ET :
I personally always have this in the back of my mind. Lots of patients are started on “offending” bladder medications without properly evaluating whether they actually work for them. Often, they don’t, but the prescriptions continue anyway. I can often discontinue these medications without any problems. A few patients want to restart them, but surprisingly, that’s far from the majority. I think we should be much better about trialing medication pauses for bladder medications! For allergy medication, I almost always start with Fexofenadine, which has no significant anticholinergic activity. When finances or insurance make that difficult, I usually start with Cetirizine or Loratadine, as they have very low (but not zero) anticholinergic effects. If I see someone taking daily Diphenhydramine (Benadryl), which is one of the worst offenders, I generally have a conversation with them about switching.
2026-08-29 17:29:20
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ursouthbay_realtor
ursouthbay_realtor :
Can you name the medications?
2026-08-31 18:17:58
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heatherkpsyd
Heather K. PsyD :
Is there a way to decrease or reverse that risk? I had to take a TCA for a bit, idk, maybe a year, or a bit less than that. I mo longer take it and haven’t for a while and take nine of those other categories. Does that risk stay with you after discontinuation over time? Is there anything to do about it besides not taking the med?
2026-08-29 14:59:24
1
freelandmcneely
freelandmcneely :
Do those stay in your system after you stop them?
2026-08-29 14:40:04
0
hapsss_df6767
Paz ⚡️snaxz 🍬 :
So I’m dead I guess
2026-08-31 15:01:27
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deirdre.finney
Deirdre Finney :
Check the pronunciation of contributing
2026-08-29 19:28:29
0
meowamine
meowamine :
Six percent increase does not seem like a lot. What are the confidence intervals on that estimate?
2026-08-29 17:53:08
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alouise37
user5354629473140 :
When the study came out my mom (then 75 yrs old) was taken off amitriptyline (which she had been on for 20 years) and Vesicare (7 years on that one). I think it was too late for her-– she's happy and physically healthy now, but stage six Alzheimer's😢
2026-08-29 19:54:56
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beapitt
beapitt :
As a petient, I am just grateful for the 13 seconds that a doctor spends with me every time. We don’t talk, she just writes scripts.
2026-08-29 18:28:11
0
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