@derekweyhrauch_md: Lp(a) Medicine Update! Pelacarsen: - Antisense oligonucleotide targeting LPA mRNA - ↓ Lp(a) up to ~80% - Phase III Lp(a)HORIZON: 8,323 pts - Outcomes expected late 2026 - Possible approval: 2027 Olpasiran: - siRNA targeting LPA mRNA - ↓ Lp(a) ~95+ to at higher doses - Phase III OCEAN(a)-Outcomes: 7,297 pts - Expected completion: 2028 Lepodisiran: - Long-acting siRNA - ↓ Lp(a) ~90 to 95% - Potentially only 1 or 2 injections/yr - Phase III ACCLAIM-Lp(a): ~17,300 patients - Expected completion: 2029 Muvalaplin: - Oral small molecule preventing apo(a)-apoB100 assembly - ↓ Lp(a) ~70 to 85% - Phase III MOVE-Lp(a): ~10,450 patients - Expected completion: 2031 Zerlasiran: - siRNA targeting LPA - ↓ Lp(a) ~80 to 97% - Phase II complete / Phase III-ready - Further development pending Safety: Reassuring so far, with mild injection site reactions the main issue with injectable therapies. Lp(a) lowering is also being studied as a potential treatment to slow calcific aortic stenosis, another disease strongly associated with elevated Lp(a). The first major answer should come from pelacarsen’s HORIZON trial in late 2026. If positive, we could see the first dedicated Lp(a)-lowering medication as early as 2027! - #doctor #medicine #health #wellness #prevention - Disclaimer: The contents of this video are for informational purposes only and are not intended to be medical advice, diagnosis, or treatment, nor to replace medical care. The information presented herein is accurate and conforms to the available scientific evidence to the best of the presenter/author’s knowledge as of the time of posting. Always seek the advice of your physician or other qualified health provider with any questions regarding any medical condition. Never disregard professional medical advice or delay seeking it because of information contained in this channel/post.
derekweyhrauch_md
Region: US
Saturday 29 August 2026 18:52:54 GMT
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nursejeff68 :
Why did mother nature make the Lp (a)? What harm will occur by taking it away?
2026-09-01 12:30:32
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kingkrustenkse :
For what levels of LP(a) will those be used for initally?
2026-09-01 05:19:16
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Ozawa2222 :
" I just finished a triathlon", pretty sad dude that you had to work that in.
2026-08-30 13:24:47
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Movie Nerd :
Thanks for the update ! Concise and quick . I guess the big question will be does lower lp(a) lead to a lower mortality rate. We know what elevated levels cause but does lower levels improve cardiac health outcomes. Only time will tell I guess.
2026-08-29 21:25:50
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Artrulesme :
I am in the Lepodisiran trial.
2026-08-29 23:03:28
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Chris_H :
These studies, HORIZON specifically, keeps getting pushed back because event rates are low. Many of the patients are aggressively lowering ApoB and LDL, even with elevated lp(a).
2026-08-29 20:21:23
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Bill0912 :
I was normal weight and good cholesterol at 45 and had a heart attack. LPa. It’s 195 now 15 years later but waiting for new treatments
2026-08-30 02:15:13
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Classically Inclined :
Not yet available. But soon
2026-08-30 01:57:24
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..... :
I just found out i have elevated lpa and some mild aortic calcification. I hope the new medications won't be exorbitantly expensive.
2026-08-29 20:57:13
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jMarr :
any cardiologist you would recommend in orange county ca?
2026-08-30 17:45:02
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Javajean :
I am in one of these trials. I have no side effects. However it’s important to remember that since these trials are double-blinded, the trial participants do not know if they’re getting the drug or placebo. Also, as others have stated, it remains to be seen if lowering Lp(a) will result in improved clinical outcomes. I remember when we thought raising HDL numbers would improve clinical outcomes, but now this has been disproven.
2026-08-29 22:35:03
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Bern | Migraine Advocate 💙📚 :
Heck yes. And now we just need to see if these meds lowering lpa(a) actually leads to preventing cardiovascular events, right?
2026-08-30 01:49:57
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user85812491382611 :
When are these a available. Don’t torture us… we need to know… NOW
2026-08-30 05:03:56
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Kelli V :
But are the effects of lipo(a) themselves the actual problem? What if you have someone with over 200’s but their apo A and lipid profile is normal? Is it necessary?
2026-08-29 23:03:17
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cheersandspirits :
Does this help when your blood work numbers are boosted by high T converted to estrogen?
2026-08-29 22:52:06
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Crest ❌ :
I can hear the patients already.. “naw. I’m good. I take beet root”
2026-08-30 15:17:24
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TJ :
Sounds great! No excuse to have heart disease now. Except I find GP’s don’t focus on it enough. I had to request statins, and eventually a dose increase as the GP didn’t seem too interested
2026-08-30 08:34:45
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Ashley May :
You made a comment about the liver with LPa. Does that mean having a fatty liver could potentially be a side effect for someone if their LPa is elevated? Or
2026-08-30 14:35:21
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Kelli V :
What is the best way to test for calcified aorta? Would coronary calcium score even look at this? Are there any screenings that do?
2026-08-29 23:04:34
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jackd..22 :
i had no idea there were medications for this. need to look into it.
2026-08-30 01:18:25
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Oubay :
In development not available as of yet . Looking forward to it .
2026-08-29 20:16:52
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Carrie :
Is the same as cholesterol?
2026-08-29 21:42:01
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peterdemartini5 :
Is there any concrete proof that the body might need some LPa? Can 80% reduction actually be better for you than 95% reduction? Body produces LPa due a reason?
2026-08-30 20:25:25
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user5828538750387 :
If you are over 70 , should you wait or it’s too late ?
2026-08-30 00:07:20
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R&R :
LIPFENDRA? PRAULENT? Of all you mentioned…..which have least side effects??
2026-08-29 22:22:05
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