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Survodutide might be WAY more interesting than just another weight-loss drug. 🧬🔥 Everyone is watching the scale. I’m watching the liver. Survodutide is an investigational dual GLP-1 + glucagon receptor agonist and the Phase 3 data are getting seriously interesting. In people with obesity and at-risk fatty liver disease (MASLD), 84.2% of participants receiving survodutide achieved at least a 30% reduction in liver fat at 48 weeks versus 24.3% with placebo. Even crazier? About 6 out of 10 reached liver fat levels below 5%.  And in the separate obesity trial, survodutide produced up to 16.6% average weight loss over 76 weeks.  But here’s what fascinates me. Survodutide isn’t simply making people eat less. We’re manipulating the same brain-gut-metabolic signaling network involved in hunger, satiety, energy balance and metabolic regulation. Preclinical research published this year showed survodutide activating brain regions involved in appetite regulation through its GLP-1 activity.  So maybe the bigger conversation isn’t: “How much weight can this drug make someone lose?” Maybe it’s: “Why was the metabolic system dysregulated enough to produce obesity and fatty liver in the first place?” The drugs are getting better. Now our understanding of the biology needs to get better too. 🔬 Educational purposes only. Not medical advice. Survodutide remains investigational, and these results should not be interpreted as establishing it as an approved treatment. #Survodutide #GLP1 #Glucagon #WeightLoss #Obesity
Survodutide might be WAY more interesting than just another weight-loss drug. 🧬🔥 Everyone is watching the scale. I’m watching the liver. Survodutide is an investigational dual GLP-1 + glucagon receptor agonist and the Phase 3 data are getting seriously interesting. In people with obesity and at-risk fatty liver disease (MASLD), 84.2% of participants receiving survodutide achieved at least a 30% reduction in liver fat at 48 weeks versus 24.3% with placebo. Even crazier? About 6 out of 10 reached liver fat levels below 5%. And in the separate obesity trial, survodutide produced up to 16.6% average weight loss over 76 weeks. But here’s what fascinates me. Survodutide isn’t simply making people eat less. We’re manipulating the same brain-gut-metabolic signaling network involved in hunger, satiety, energy balance and metabolic regulation. Preclinical research published this year showed survodutide activating brain regions involved in appetite regulation through its GLP-1 activity. So maybe the bigger conversation isn’t: “How much weight can this drug make someone lose?” Maybe it’s: “Why was the metabolic system dysregulated enough to produce obesity and fatty liver in the first place?” The drugs are getting better. Now our understanding of the biology needs to get better too. 🔬 Educational purposes only. Not medical advice. Survodutide remains investigational, and these results should not be interpreted as establishing it as an approved treatment. #Survodutide #GLP1 #Glucagon #WeightLoss #Obesity
The dad left his four-month-old with injuries similar to a ‘car crash’ victim. Tony Bartlett, 39, was found guilty of murdering his baby son, Atticus, after he was violently shaken. Bartlett, of Axminster in Devon, was convicted by jury for causing severe injuries to his baby son when he shook him at home in Chard, Somerset, on 16 July 2022. Bartlett and his former partner Evelyn Ballentyne had gone on their first night out since the birth of their son. When they arrived home, the mother went upstairs and Bartlett was left alone to feed Atticus. A court heard that by the time she returned downstairs, her son looked
The dad left his four-month-old with injuries similar to a ‘car crash’ victim. Tony Bartlett, 39, was found guilty of murdering his baby son, Atticus, after he was violently shaken. Bartlett, of Axminster in Devon, was convicted by jury for causing severe injuries to his baby son when he shook him at home in Chard, Somerset, on 16 July 2022. Bartlett and his former partner Evelyn Ballentyne had gone on their first night out since the birth of their son. When they arrived home, the mother went upstairs and Bartlett was left alone to feed Atticus. A court heard that by the time she returned downstairs, her son looked "lifeless". Atticus was taken to Musgrove Park Hospital before being transferred to Bristol Royal Hospital for Children, where he died just before midnight on 23 July 2022. Bartlett, formerly a postman, insisted he had not harmed his son and refused to admit he was drunk. His legal team suggested Evelyn Ballentyne could have caused the fatal injuries. She was initially arrested alongside Bartlett but was never charged and appeared as a prosecution witness during the trial. Medical experts told the court Atticus had sustained severe internal injuries to his brain and spinal cord, leaving the child with injuries “that were consistent with a car crash, or a fall from a height.” After the hearing, Detective Superintendent Lorett Spierenburg said: “This is a devastating case in which a very young baby has lost his life as the direct result of a violent and cruel act. “The loss of Atticus has had a profound effect on all those who loved him.” Bartlett is expected to be given life in prison when he is sentenced at Bristol Crown Court on 24 July. #5news #bodycam #baby

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