@heatherhirschmd: “Estrogen dominance” gets talked about a lot, but it’s often misunderstood. During perimenopause, progesterone naturally starts to decline while estrogen can fluctuate dramatically. That means there may be times when estrogen is very high and progesterone is very low. And importantly: having this pattern does not automatically mean estrogen therapy is off the table. Hormone levels in perimenopause are constantly shifting, which is one reason a single lab result rarely tells the whole story. If you’re navigating perimenopause and trying to make sense of your hormones, this is an important distinction to understand. Check out jointhecollaborative.com and get matched with a Collaborative clinician who can walk you through your symptoms and your options.