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@panjshiri_0113: #شهیداحمدشاه_مسعود_قهرمان_ملی_کشور
Mir Panjshiri ོ
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Region: US
Wednesday 02 September 2026 20:46:43 GMT
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ویتی نینی :
جانم هستن تاجک❤️❤️❤️❤️❤️
2026-09-03 05:25:37
0
samet :
🥰🥰🥰
2026-09-03 11:16:46
0
خمـٜ۪ྱོارِی :
❤️
2026-09-03 01:44:47
0
ادریــــــس :
🫶♥️
2026-09-03 00:26:39
0
ساقی شار :
❤️❤️❤️
2026-09-03 00:05:38
0
𝑬𝒅𝒓𝒊𝒔 :
🖤
2026-09-02 23:51:04
0
ᗩ Y ᗩ ᑎ𓍼ོ :
♥️♥️
2026-09-02 21:35:56
0
Baes :
🖤🕊️💚
2026-09-02 20:54:27
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﮼فردوس :
♥️
2026-09-02 20:53:58
0
:Ŧáĵìķ Ŧàbàŕ: :
❤️❤️❤️
2026-09-02 20:50:15
0
𝐒𝐡𝐚𝐡𝐢𝐧 :
♥️♥️♥️
2026-09-02 20:47:44
0
𓆩.PJR乂YAQOOB.𓆪 :
🥰🥰🥰
2026-09-09 08:51:36
0
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HY Pulm . . . . A) Antibodies to postsynaptic acetylcholine receptors ❌ Associated with myasthenia gravis, not lung cancer Myasthenia shows fluctuating weakness with repetitive use; this patient has progressive weakness from malignancy Clinical context (smoker + lung mass) = paraneoplastic syndrome, not autoimmune neuromuscular disorder B) Parathyroid hormone-related peptide (PTHrP) secretion ❌ Associated with squamous cell lung cancer, not small cell PTHrP causes hypercalcemia (would raise potassium, not lower it) This patient's electrolyte pattern (high sodium, low potassium, metabolic alkalosis) doesn't fit PTHrP C) Prior occupational asbestos exposure ❌ Asbestos is primarily associated with mesothelioma This patient has a central hilar mass (small cell), not the pleural-based tumors seen with mesothelioma D) Elevated urinary 5-hydroxyindoleacetic acid (5-HIAA) ❌ Associated with bronchogenic carcinoid tumors (young patients, indolent course) This elderly patient has aggressive disease with proximal weakness + electrolyte abnormalities, not carcinoid syndrome (flushing, diarrhea) E) Autoantibodies to voltage-gated calcium channels ✅ SCLC is the classic malignancy for Lambert-Eaton myasthenic syndrome Weakness improves with repetitive muscle use (opposite of myasthenia gravis) Electrolyte pattern (high sodium 151, low K 2.9, high bicarb 32) = KEY: ACTH-secreting SCLC. Excess cortisol acts like aldosterone → sodium retention, potassium wasting, metabolic alkalosis (cortisol drives H+ excretion) Teaching: SCLC has MULTIPLE paraneoplastic syndromes — ACTH-secretion (Cushing electrolytes) + Lambert-Eaton antibodies (proximal weakness) #USMLE #meded #Step1 #Step2CK #medstudent
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