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@chinn9x:
Chin Chin Nguyễn
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Region: VN
Friday 04 September 2026 15:54:32 GMT
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In a major step closer toward establishing a CURE for Type 1 Diabetes, Sana Biotechnology just announced MAJOR news where a person with T1D was the first human EVER to receive islet cell transplants WITHOUT immunosuppression. Their HypoImmune Technology (HIT) uses CRISPR gene editing to modify transplanted islet cells to evade the immune system. This is a huge deal because a cure for T1D requires two major goals: 1. Restore insulin production 2. Protect that insulin production from destruction by the immune system Previously, there had only been major progress with goal #1, primarily through Vertex Pharmaceuticals and their success in implanting Stem Cell-derived islet cell (which produce insulin) in humans. These have been so successful that many of their subjects no longer require injected insulin. However, a major limitation to this product was that subjects required lifelong immunosuppression, which has major risks and potential long-term safety concerns. This study by Sana is meaningful because it is the first successful (so far) attempt at creating a solution that avoids destruction by the immune system. While this study utilized islet cells from a deceased human donor (which is not a long-term solution because these are hard to come by), the HypoImmune Technology (HIT) should theoretically be usable for stem-cell derived islet cells (which are able to be produced in large quantities), whether they are made by Vertex or Sana (who is working on their own stem-cell derived islet cells). #t1d #medtronicdiabetes #tandemdiabetes #jdrf #Omnipod5 #omnipod #apitiktok #TikTokPartner
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