@8pufu00d: Are GLP-1 receptor agonists (like semaglutide and tirzepatide) doing more than just driving weight loss and glycemic control? Emerging observational studies and clinical trials suggest they may reduce the incidence of obesity-associated cancers and improve overall survival in active cancer patients! Let's break down the scientific mechanisms: 🩺🫁👇 Hi, I'm Dr. Cleo Riles, Harvard-trained cancer researcher and science communicator. Welcome to Part 1 of my ongoing GLP-1s & Cancer Research Series: 🧬 1. THE METABOLIC & TUMOR INTERSECTION: 13 Obesity-Associated Cancers: Obesity drives chronic low-grade inflammation, hyperinsulinemia, elevated IGF-1 (insulin-like growth factor 1), and altered adipokines (leptin/adiponectin ratio)—all of which promote tumor cell proliferation and angiogenesis. Direct vs. Indirect Pathways: GLP-1s lower cancer risk indirectly through substantial adiposity loss and improved insulin sensitivity. However, researchers are also investigating direct GLP-1 receptor signalling in immune cells (e.g., NK cell restoration) and tumor microenvironments. 📊 2. WHAT THE EARLY SIGNALS SHOW: Incidence Reduction: Large retrospective cohort studies show significant risk reductions in colorectal, pancreatic, endometrial, ovarian, and breast cancers compared to traditional anti-diabetic medications like insulin or sulfonylureas. Active Cancer Outcomes: Emerging studies are evaluating whether GLP-1 use during or after active treatment improves recurrence-free survival (RFS) and treatment response (e.g., reversing chemotherapy resistance driven by metabolic dysfunction). 🔬 3. WHAT TO WATCH FOR IN THIS SERIES: Over the next several weeks, I'll be breaking down landmark studies, real-world comparative effectiveness data, and my own upcoming research presentation on GLP-1 use and breast cancer outcomes! 👇 What questions do you have about GLP-1 medications and cancer risks? Leave them below! #GLP1 #Oncology #CancerResearch #Ozempic #Wegovy

181

There are no more comments for this video.

To see more videos from user @8pufu00d, please go to the Tikwm homepage.