@dr.zac.spiritos: One thing that is almost part and parcel of MCAS is an incredible reactivity to medications. A “normal” starting dose may just be way too high in someone with overactive mast cells. So instead of starting where we typically do, I often start much lower and move up slowly. Sometimes that means breaking a pill into smaller pieces. If there’s a liquid version, that can be even easier because you can start with a tiny dose and inch your way up. And sometimes we’ll even compound a medication at a lower dose just to make that process possible. Reactions to medications are really common in MCAS, and starting with less can sometimes make a big difference. The hope is that your body gets used to the medication, you slowly build the dose over time, and eventually you’re able to get the benefit without getting knocked over by side effects right out of the gate. #mcas #heds #dysautonomia #mastcellactivationsyndrome #hypermobility

Dr. Zac Spiritos
Dr. Zac Spiritos
Open In TikTok:
Region: US
Sunday 13 September 2026 03:37:19 GMT
17970
613
82
28

Music

Download

Comments

elizabethbell715
Elizabeth Bell715 :
im always the "rare side effects are your normal side effects" person
2026-09-17 00:35:01
1
mexicoamanda
Mexico Amanda :
a Dr tried to give me tramadol today. When I said no way, he said take half, me nope, him 1/3, me I'll buy it if I become desperate 😅
2026-09-16 06:47:30
0
wolramc
CMarlow :
This explains a lot
2026-09-16 12:39:54
0
ambz311
Jewel of the Pines :
I have MCAS but I have the opposite issue. I have to take higher than average doses of a lot of meds for them to even work. It’s like I just dont metabolize them.
2026-09-13 04:59:17
22
pink__chi
Pink_chi :
How is MCAS diagnosed? Doctors keep saying my son doesn't have MCAS and that everything looks normal, but then all of the meds they have him in so he can eat are typically used for MCAS......getting answers feels impossible
2026-09-13 05:24:01
4
magnolia_camellia
⚜️ :
The CRNA who did my anesthesia for my C-Section didn’t believe me and gave me so much that it became a full on emergent event. I have a LOT of trust issues now!
2026-09-13 05:22:39
5
amandamagee07
Mandy350 :
I take reactions to near every medication..im now allergic to all antibiotics
2026-09-14 00:24:36
3
louisebelcher999
Sample of Soul 999 ❌ :
I never take the full dose on supplements at first. last time I did I had horrible cramping that lasted hours and that was a multivitamin 😮. I haven't officially been diagnosed but having to take Zyrtec for over 30 years to avoid pressure induced hives and near constant nasal congestion in addition to some new perimenopauseal developments points toward MCAS 😂😱
2026-09-14 01:22:43
1
poetrynerdd
poetrynerdd :
Does this mean that I might not actually have a hive reaction if I titrate up slowly?
2026-09-14 01:05:22
1
shealynn1111
Shealynn :
As in it triggers flares? Is something I’m on possibly the reason I feel like I’m in a constant flare?
2026-09-14 00:05:54
1
sloeaf
Sloe AF :
I have MCAS pretty bad and I am the opposite. Meds don’t work well. I have pretty high doses because the “typical” starting does nothing.
2026-09-15 04:43:18
1
kirsten_haines23
Kirsten_Haines :
I have a question. What other reasons could cause this?
2026-09-13 03:40:42
1
kinpelican
Kelly 💖 UGC + Lifestyle :
THANK YOU! I try to tell my dr this and I just got to the point of “I’m not picking it up unless I can break the pill” 😂 he’s finally catching on.
2026-09-13 18:44:06
1
jess_cares
Jess💚 :
PEDIATRIC DOSING 👍
2026-09-13 19:48:27
2
its.sahnya
its.sahnya :
I metabolize meds super fast. So usually they stop working super quick… or I end up maxing my doses
2026-09-13 15:49:30
1
bre.tar
Bre 🇨🇦 :
Yes!!! You are the first person in a medical profession I’ve heard say this. I always start at a fraction of a regular dose and titrate up. I open capsules up and add to water or ask for chewable versions so I can cut up the meds.
2026-09-14 00:15:37
2
missmamabee
missbee🇨🇦🏴󠁧󠁢󠁳󠁣󠁴󠁿🇮🇪 :
I had a full-body itch w rash w montelukas, started at wk 2 progressed to full-body by wk 3 so I stopped the meds and took another wk to clear. Dr told me it "couldnt happen"...but yet...it did
2026-09-14 00:03:48
1
kaizenwisdom
Kaizenwisdom :
I wish you were in Florida. I would drive hours to wherever you were just to be seen by you!
2026-09-13 15:21:20
1
pierce0m
pierce :
On a half dose of literally anything: this is not good. NOT good at all. 😭
2026-09-14 01:58:21
0
divine_revs
Divine_Revs :
This is a CONSTANT argument with my clinic....🙄
2026-09-13 13:05:59
2
nathalievandijk5
Nathalie van Dijk :
yep. 1/4 of the minimum dose at first try for anything and bam
2026-09-13 15:56:17
2
guavagirl808
guavagirl808 :
You are the first doctor, until recently, in my life that gets this. I finally started doing this on my own until I found a doctor who actually listens and trusts me. He doesn't know the mechanism, but believes me and lets me go slow and/or never increase.
2026-09-13 14:36:32
3
chronicallycuddlycrafts
Laurie S | Chronically Cuddly :
Told my dr today that another doc has started me on 0.1mg of a med (4% of the normal starting dose). She asked if we could start any lower. Mam, this med , 0.1mg is basically like one tear drop of liquid, I don’t think it’s possible 😅 but I appreciate her concern for my safety
2026-09-14 21:34:13
1
mkmacleanauthor
Meg🇨🇦🌈📚 :
wait....but also hEDS which reduces effectiveness...?. 😳 oh boy, my body is fun.
2026-09-13 21:01:40
2
pepper_n_penny
Pepper and Penny🐕🐶 :
I'm tired of this grandpa! 😩
2026-09-13 21:48:47
1
To see more videos from user @dr.zac.spiritos, please go to the Tikwm homepage.

Other Videos


About