@coach.agz: Its metabolites are the problem: Tren breaks down into 17-epitrenbolone and trendione, and those metabolites stay biologically active at the receptor. That's part of why side effects linger past the point where you'd expect the compound to be cleared. It's a glucocorticoid receptor antagonist: Tren blocks cortisol at the receptor in muscle tissue, which is a real part of why it spares tissue so aggressively. It's also why some people feel flat, anxious, or dysregulated on it — you're interfering with the body's stress signaling system, not just building muscle. It raises IGF-1 locally while lowering it in blood: Tren increases IGF-1 expression inside muscle tissue but tends to leave serum IGF-1 flat or suppressed. Your bloodwork can look unremarkable while the tissue-level signaling is anything but. Comment "TREN" if you want to learn what to watch on bloodwork before it becomes a problem. #bodybuilding #tren
