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Saturday 19 September 2026 02:43:45 GMT
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The breakthrough paper reviewed six years of data using the broader Consensus-2 diagnostic criteria and here are some key takeaways: -Stricter
The breakthrough paper reviewed six years of data using the broader Consensus-2 diagnostic criteria and here are some key takeaways: -Stricter "Consensus-1" rules (requiring a massive, usually impossible-to-catch tryptase spike during a flare) can cause underdiagnosis (this personally happened to me when I first saw an immunologist, an Integrative GP was the only doctor trained in the consensus 2 criteria I could find) -Many MCAS patients never show significant tryptase elevations but still experience severe multi-systemic physical symptoms -Validating MCAS through clinical symptoms and positive treatment response changes a patient's quality of life, often after decades of medical neglect -The fear that broader criteria would lead to "overdiagnosis" has not been realised #mcas #chronicillness #invisibleillness #mecfs #eds

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