@psychingout: Day 5/100| Stopping antidepressants? Here’s what the evidence tells us. A 2024 systematic review and meta-analysis found that 31% (around 1 in 3) experienced at least one discontinuation symptom after stopping an antidepressant. After accounting for symptoms also reported after placebo, around 1 in 6–7 were estimated to be directly attributable to discontinuation. Remember FINISH: Flu-like symptoms • Insomnia • Nausea • Imbalance • Sensory disturbances • Hyperarousal Venlafaxine and paroxetine are associated with more discontinuation symptoms, while fluoxetine tends to cause fewer due to its long half-life. Relapse is a separate consideration. In the ANTLER trial, relapse occurred in 56% of people who discontinued antidepressants compared with 39% who continued over 52 weeks. If you’re considering stopping an antidepressant, consult your doctor or prescriber. References: Davies et al. (2024), The Lancet Psychiatry Horowitz & Taylor (2022), BJPsych Advances Lewis et al. (2021), New England Journal of Medicine #100daysto2027 #psychiatry #antidepressants #discontinuation #relapse

Dr Nafisa | Psyching OUT!

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Saturday 26 September 2026 19:25:48 GMT