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@nawroz.anwarr:
naz.anwar
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Thursday 01 October 2026 17:51:01 GMT
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La queilitis granulomatosa de Miescher es una forma de granulomatosis orofacial que se caracteriza por una edema persistente o recurrente de uno o ambos labios, debida a una inflamación granulomatosa no caseificante. Afecta sobre todo a adultos jóvenes. Puede ser aislada, formar parte del síndrome de Melkersson-Rosenthal, que combina edema labial, lengua fisurada y parálisis facial periférica recurrente, o ser la manifestación oral de una enfermedad de Crohn o de una sarcoidosis. Se han implicado alergias a alimentos y aditivos, como el cinamaldehído o el benzoato, y factores genéticos. Al inicio aparecen episodios de edema labial blando que duran horas o días y se resuelven, pero con el tiempo el edema se vuelve persistente, firme, indolora, con fisuras, descamación y cambio de color. También pueden afectarse las mejillas, los párpados, la frente y las encías. La biopsia muestra granulomas no caseificantes, edema y linfangiectasias, aunque al inicio pueden ser escasos. El estudio incluye descartar enfermedad de Crohn, sarcoidosis, infecciones, angioedema y realizar pruebas epicutáneas. El tratamiento incluye corticoides intralesionales, minociclina o doxiciclina, dietas de exclusión cuando hay alérgenos, y en casos refractarios inmunomoduladores o biológicos. Dr. Javier Rosero · Dermatólogo · Quito – Ecuador · Contacto: 0982453672 Imágenes clínicas de referencia: Bolognia. Dermatología. © Elsevier España, 2025. Material docente, no son casos propios. #labios #granulomas #dermatologia #dermatologoquito #quito #medicina
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