@artemis.dermatologia: El nevo combinado es un nevo melanocítico formado por dos o más poblaciones distintas de melanocitos dentro de la misma lesión. La combinación más frecuente es la de un nevo común, intradérmico o compuesto, con un nevo azul, aunque también puede combinarse con un nevo de Spitz, un nevo de células epitelioides pigmentadas o un componente con pérdida de BAP1. Suele aparecer en adultos jóvenes y se localiza en cabeza, cuello, tronco y extremidades. Clínicamente se presenta como un nevo de color marrón claro, con pigmentación uniforme, que contiene una pápula o zona de color marrón oscuro, azul o negro, excéntrica o central, como en la imagen. Esta imagen de dos colores puede simular un melanoma que surge sobre un nevo previo, por lo que genera preocupación. En la dermatoscopia se observa un área azul o negra homogénea bien delimitada dentro de un patrón reticular o globular regular. La histopatología muestra un nevo convencional de melanocitos pequeños asociado a una población de melanocitos dérmicos dendríticos o epitelioides pigmentados con melanófagos; en los nevos combinados con células grandes epitelioides se recomienda estudiar BAP1. El diagnóstico diferencial incluye el melanoma sobre nevo, el nevo azul, el nevo de Spitz pigmentado y el nevo recidivante. Es benigno; la extirpación se reserva para los casos en que no puede descartarse un melanoma con la clínica y la dermatoscopia. Dr. Javier Rosero · Dermatólogo · Quito – Ecuador · Contacto: 0982453672 Imágenes clínicas de referencia: Bolognia. Dermatología. © Elsevier España, 2025. Material docente, no son casos propios. #lunares #melanoma #dermatologia #dermatologoquito #quito #medicina

artemisdermatologia
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