@dr_malak5.6: ๐Ÿšจ๐Ÿ’Š PHARMACY POP QUIZ | BRAND vs. GENERIC! PHARMACY STUDENTS! ๐ŸŽ“ ๐Ÿค” What is the BRAND NAME of DAPAGLIFLOZIN? โณ You have 5 seconds! Choose A, B, C, or D! โœ… CORRECT ANSWER: B. FARXIGA! ๐Ÿ’™ ๐Ÿ’Š GENERIC: Dapagliflozin ๐Ÿท๏ธ BRAND: Farxiga ๐Ÿ”ต DRUG CLASS: Sodium-glucose cotransporter-2 (SGLT2) inhibitor ๐ŸŽฏ FDA-APPROVED USES: โœ… Improve glycemic control in type 2 diabetes โœ… Reduce heart failure hospitalization in appropriate adults with type 2 diabetes and cardiovascular risk factors โœ… Reduce cardiovascular death, heart failure hospitalization, and urgent heart failure visits in adults with heart failure โœ… Reduce CKD progression and related cardiovascular or kidney complications in eligible patients ๐Ÿง  MECHANISM OF ACTION: Dapagliflozin blocks SGLT2 in the proximal renal tubule. โฌ‡๏ธ Glucose reabsorption โฌ†๏ธ Urinary glucose excretion โฌ‡๏ธ Blood glucose It also provides heart and kidney benefits that extend beyond glucose lowering. ๐Ÿ’Š HIGH-YIELD NAPLEX DOSING: ๐Ÿ”น Type 2 diabetes: Usually start at 5 mg once daily; may increase to 10 mg daily. ๐Ÿ”น Heart failure or CKD indications: Commonly 10 mg once daily. ๐Ÿ”น Kidney function must be checked before treatment. eGFR thresholds vary by indication. โš ๏ธ IMPORTANT ADVERSE EFFECTS: ๐Ÿ”ธ Genital fungal infections ๐Ÿ”ธ Increased urination ๐Ÿ”ธ Volume depletion and hypotension ๐Ÿ”ธ Urinary tract infections ๐Ÿšจ Euglycemic diabetic ketoacidosis (DKA) ๐Ÿšจ Rare Fournier gangrene โญ HIGH-YIELD NAPLEX PEARLS: ๐Ÿ’ก DAPAGLIFLOZIN = FARXIGA! ๐Ÿ’ก EMPAGLIFLOZIN = JARDIANCE! ๐Ÿ’ก CANAGLIFLOZIN = INVOKANA! ๐Ÿ’ก ERTUGLIFLOZIN = STEGLATRO! ๐Ÿ’ก SGLT2 inhibitors promote glucose excretion through the urine. ๐Ÿ’ก Dapagliflozin is NOT used to improve glycemic control in type 1 diabetes. ๐Ÿ’ก Its glucose-lowering effect decreases as kidney function declines, although kidney and heart benefits may still support its use in eligible patients. ๐Ÿ’ก Dapagliflozin should generally be withheld for at least 3 days before major surgery or procedures involving prolonged fasting. ๐Ÿšจ EUGLYCEMIC DKA WARNING: Patients can develop ketoacidosis even without severely elevated blood glucose. Watch for: ๐Ÿ”ธ Nausea or vomiting ๐Ÿ”ธ Abdominal pain ๐Ÿ”ธ Rapid breathing ๐Ÿ”ธ Unusual fatigue Seek urgent evaluation if these symptoms occur. ๐Ÿฉบ PATIENT COUNSELING: โœ… Take once daily as prescribed. โœ… Maintain adequate hydration. โœ… Practice good genital hygiene. โœ… Report symptoms of genital infections. โœ… Follow sick-day and perioperative medication instructions. โœ… Monitor kidney function and blood pressure as recommended. ๐Ÿง  MEMORY TIP: ๐Ÿ’™ DAPAGLIFLOZIN = FARXIGA ๐Ÿ’š EMPAGLIFLOZIN = JARDIANCE ๐Ÿ’ฌ PHARMACY STUDENTS: Which SGLT2 inhibitor is marketed as JARDIANCE? ๐Ÿ‘‡ Comment your answer! ๐Ÿ“Œ SAVE this quiz for your NAPLEX brand/generic review! ๐Ÿ’™ Follow @dr_malak5.6 for daily NAPLEX quizzes, brand and generic names, diabetes medications, kidney protection, and high-yield pharmacy pearls! #NAPLEX #NAPLEXPrep #Dapagliflozin #Farxiga #Jardiance

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