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Friday 30 October 2026 13:12:22 GMT
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Your immune system may be quietly flagging gut disease a decade before any symptoms show up. Researchers led by Dr. Arno Bourgonje (University Medical Center Groningen and the Icahn School of Medicine at Mount Sinai) looked back through blood samples from 500 people — 200 who later developed Crohn's disease, 200 who later developed ulcerative colitis, and 100 healthy controls. The 2,000 samples were taken at diagnosis and roughly 2, 4, and 10 years before it, and the team profiled antibody responses to about 357,000 antigens from bacteria, viruses, food, and the immune system itself. People who later developed inflammatory bowel disease (IBD) had noticeably narrower antibody diversity than healthy people, and distinct antibody patterns were already visible up to 10 years before diagnosis. Using machine learning on those patterns, the models distinguished future Crohn's cases from healthy controls with an accuracy score of 0.90, and future ulcerative colitis cases at 0.84 (where 1.0 would be perfect). The patterns could even separate people who would develop complicated Crohn's disease from those whose disease stayed less complicated, about 10 years out, at 0.85. This is a proof of principle, not a test you can ask your doctor for yet. The researchers stress it still needs validation in independent, more diverse populations before it could ever become a screening tool — and it shows a link in stored blood samples, not proof that any one infection or antibody causes IBD. Educational only, not medical advice. #GutHealth #IBDResearch #CrohnsDisease #UlcerativeColitis #BetterLifeDaily
Your immune system may be quietly flagging gut disease a decade before any symptoms show up. Researchers led by Dr. Arno Bourgonje (University Medical Center Groningen and the Icahn School of Medicine at Mount Sinai) looked back through blood samples from 500 people — 200 who later developed Crohn's disease, 200 who later developed ulcerative colitis, and 100 healthy controls. The 2,000 samples were taken at diagnosis and roughly 2, 4, and 10 years before it, and the team profiled antibody responses to about 357,000 antigens from bacteria, viruses, food, and the immune system itself. People who later developed inflammatory bowel disease (IBD) had noticeably narrower antibody diversity than healthy people, and distinct antibody patterns were already visible up to 10 years before diagnosis. Using machine learning on those patterns, the models distinguished future Crohn's cases from healthy controls with an accuracy score of 0.90, and future ulcerative colitis cases at 0.84 (where 1.0 would be perfect). The patterns could even separate people who would develop complicated Crohn's disease from those whose disease stayed less complicated, about 10 years out, at 0.85. This is a proof of principle, not a test you can ask your doctor for yet. The researchers stress it still needs validation in independent, more diverse populations before it could ever become a screening tool — and it shows a link in stored blood samples, not proof that any one infection or antibody causes IBD. Educational only, not medical advice. #GutHealth #IBDResearch #CrohnsDisease #UlcerativeColitis #BetterLifeDaily
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