@bionicmomrebuilds: The nitty-gritty on Giredestrant 👇 It's a daily pill that blocks the estrogen receptor and signals the cell to break it down. Tamoxifen blocks it. Aromatase inhibitors lower estrogen. This tries to remove the receptor. Trial: 4,170 people with early-stage ER-positive, HER2-negative breast cancer. It cut the risk of invasive recurrence or death by 30% vs standard hormone therapy. At 3 years, 92.4% vs 89.6% were alive and free of invasive disease. Overall survival data are still immature. It's also being studied in advanced disease. Side effects: joint pain 46.5% vs 45.3%, hot flashes 27.1% vs 28.5%, headache 15.2% vs 13.1%, so those were similar in both groups. Slower heart rate was higher, 11.3% vs 3.2%, mostly mild with no symptoms. Fewer stopped treatment, 5.3% vs 8.2%. FDA decision expected November 30 for early-stage ER-positive, HER2-negative breast cancer. A separate advanced application is also under review. It hasn't replaced standard therapy, and it's not right for everyone. Information only, not medical advice. If you're ER-positive, ask your oncologist about it. Have you heard of this? Tell us in the comments anything I missed. #breastcancer #BreastCancerAwareness #cancersucks #fuckcancer #bionicmomrebuilds

justkimmills🩷💙💙💙💙 :

This is me!! I have not started any med yet but this is a game changer for me.

Gabrielle M. :

Sad that it will take years to get to South Africa!! 😏

ESTHER DARKO :

great y

Kacee Leigh 🥀✨ :

Me!! I’m hoping I qualify

Gina R :

Love this info! Thank you! I’m curious if you have started back on hormone blockers? I was prescribed Anastrozole but have not started taking yet. Waiting to start after my bone density test next week. Would love to wait on this new med but doubt my oncologist will approve that.

gobiidae1 :

I want to know its bone loss profile. One of the big problems with AI is osteoporosis. Would love to get off the AI.

B123456789 :

It’s $300,000 a month…. So I wonder what insurance will approve this cause we have tamoxifen 😏

fer72 :

Sadly for premenopausal women, for longterm treatment it needs an ovarian supression too. This sucks so bad, for women before menopause it's literally only Tamoxifen, which increases risk for blood cloths and cannot be used by women with coagulation disorders (me).

Steph Risko :

ER, PR, and HER2 + (triple +) would love to have an alternative to tamoxifen that doesn't accelerate bone loss or at higher risk to cause another types of cancer

Tracey :

we have an appointment in December. I'm in Australia, so hopefully it's a gentler treatment than the current oral options and fingers crossed its proven successful. 🙏🩷

cherylmankoff :

What phase is it in the trail?💕

RachelI 🦋 :

Thank you! i have an appointment with my oncologist on Monday and I can't wait to ake her about this! I'm so tired of Letrozol and I want my estrogen back!

Robdawg :

Triple positive here, hoping I can give this a go!

tashaandromo12 :

My oncologist said no until a few yrs to show true effectiveness

DeBrA :

Had my first oncologist appointment yesterday and she said she wants me on this eventually!!!

Pennyroyal :

What are the SE compared to the AI’s

alucidlife4me :

BXGIRLMECCA :

Thanks!

Tonya V :

Me too! HER2+ ER+

dyanchrisdine :

Omg pick me! Tamoxifen is ruining my life

Irene 🇨🇦 :

Can’t we just take it to prevent cancer?